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Nystatin and Triamcinolone Acetonide Uses. If you want to treat a vaginal yeast infection try Monistat 7. Nystatin Topical Uses Side Effects Interactions Pill Images It works by stopping the growth of fungi that cause infection. . INDICATIONS USAGE. Nystatin is an over-the-counter medicated cream used to treat fungal infections of the skin. Nystatin exerts its antifungal activity against a variety of pathogenic and nonpathogenic yeasts and fungi by binding to sterols in the cell membrane. Nystatin topical may also be used for purposes not listed in this medication guide. Nystatin topical for the skin is used to treat skin infections caused by yeast. The medication will provide detailed instructions for use and any concerns should be expressed to. It is approved for use in children and is often used to treat thrush and diaper rash in infants. Here the infection can also be treated selectively. It is used to tr...